Alessandro Casini Selected Research

Afibrinogenemia (Fibrinogen Deficiency)

9/2022	Impact of Fibrinogen Infusion on Thrombin Generation and Fibrin Clot Structure in Patients with Inherited Afibrinogenemia.
1/2022	A homozygous duplication of the <I>FGG</i> exon 8-intron 8 junction causes congenital afibrinogenemia. Lessons learned from the study of a large consanguineous Turkish family.
10/2021	Novel missense mutations affecting the structure of the conserved fibrinogen Bβ C-terminal domain cause congenital hypofibrinogenemia.
1/2021	Heterogeneity of congenital afibrinogenemia, from epidemiology to clinical consequences and management.
1/2021	Clinical phenotype, fibrinogen supplementation, and health-related quality of life in patients with afibrinogenemia.
12/2020	A Novel Nonsense Mutation in FGB (c.1421G>A; p.Trp474Ter) in the Beta Chain of Fibrinogen Causing Hypofibrinogenemia with Bleeding Phenotype.
12/2019	Congenital structural and functional fibrinogen disorders: a primer for internists.
1/2019	Impaired factor XIII activation in patients with congenital afibrinogenemia.
1/2018	Clinical Consequences and Molecular Bases of Low Fibrinogen Levels.
8/2016	Diagnosis of congenital fibrinogen disorders.

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Alessandro Casini Research Topics

Disease

14	Hemorrhage 09/2022 - 09/2013
13	Afibrinogenemia (Fibrinogen Deficiency) 09/2022 - 09/2013
11	Thrombosis (Thrombus) 09/2022 - 06/2016
5	Overweight 08/2020 - 09/2012
5	Cardiovascular Diseases (Cardiovascular Disease) 05/2016 - 09/2008
4	Neoplasms (Cancer) 01/2021 - 09/2008
4	Chronic Disease (Chronic Diseases) 11/2017 - 11/2007
4	Non-alcoholic Fatty Liver Disease 06/2014 - 09/2006
3	Venous Thromboembolism 10/2022 - 09/2016
3	Pulmonary Embolism 05/2022 - 04/2013
3	Venous Thrombosis (Deep-Vein Thrombosis) 05/2022 - 06/2016
3	COVID-19 05/2022 - 01/2020
3	Fibrosis (Cirrhosis) 01/2020 - 06/2002
2	Rare Diseases (Rare Disease) 09/2022 - 06/2016
2	Congenital Dysfibrinogenemia 11/2021 - 01/2018
2	Disease Progression 01/2021 - 06/2016
2	Infections 01/2021 - 09/2003
2	Thromboembolism 12/2019 - 09/2013
2	Obesity 02/2018 - 09/2006
2	Body Weight (Weight, Body) 01/2018 - 07/2013
2	Fatty Liver 01/2018 - 09/2006
2	Thyroid Nodule (Nodule, Thyroid) 03/2017 - 01/2017
2	Hematologic Neoplasms (Hematological Malignancy) 01/2015 - 09/2014
2	Weight Loss (Weight Reduction) 06/2014 - 09/2012
2	Stroke (Strokes) 04/2013 - 06/2012
2	Insulin Resistance 10/2011 - 09/2006
2	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2010 - 03/2009
2	Alzheimer Disease (Alzheimer's Disease) 01/2010 - 09/2008
2	Liver Cirrhosis (Hepatic Cirrhosis) 11/2002 - 06/2002
1	Breast Neoplasms (Breast Cancer) 10/2022
1	Thrombophilia 09/2022
1	Critical Illness (Critically Ill) 05/2022
1	Congenital Hypodysfibrinogenemia 01/2021
1	Metrorrhagia (Spotting) 12/2020
1	Hemophilia A (Haemophilia) 12/2020
1	Uterine Hemorrhage (Uterine Bleeding) 12/2020
1	Hepatitis 10/2020
1	Thrombocytopenia (Thrombopenia) 01/2020
1	Sepsis (Septicemia) 01/2020
1	Necrotizing Enterocolitis 01/2020
1	Carcinoma (Carcinomatosis) 01/2020
1	Hyperbilirubinemia 01/2020
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2020
1	Pain (Aches) 01/2020
1	Vascular System Injuries 01/2020
1	Spontaneous Abortion (Miscarriage) 12/2019
1	Vitamin D Deficiency 11/2019
1	Hemorrhagic Disorders (Hemorrhagic Diathesis) 02/2019
1	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 12/2018
1	Intracranial Thrombosis (Cerebral Thrombosis) 01/2018
1	Colorectal Neoplasms (Colorectal Cancer) 11/2017
1	Myocardial Ischemia (Ischemic Heart Diseases) 11/2017
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 11/2017
1	Type 2 Diabetes Mellitus (MODY) 04/2017

Drug/Important Bio-Agent (IBA)

19	Fibrinogen (Factor I)FDA Link 09/2022 - 09/2013
5	FibrinIBA 09/2022 - 01/2018
4	AntigensIBA 12/2019 - 09/2013
3	AnticoagulantsIBA 01/2020 - 12/2018
3	LipidsIBA 04/2017 - 10/2011
2	Thrombin FDA Link 09/2022 - 11/2019
2	Biological ProductsIBA 09/2022 - 01/2020
2	fibrin fragment D (D-dimer)IBA 05/2022 - 01/2022
2	Heparin (Liquaemin)FDA LinkGeneric 01/2020 - 01/2020
2	Pharmaceutical PreparationsIBA 01/2020 - 11/2002
2	Factor XIII (Coagulation Factor XIII)IBA 02/2019 - 01/2019
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 05/2005
2	Glucose (Dextrose)FDA LinkGeneric 04/2017 - 05/2016
2	Triglycerides (Triacylglycerol)IBA 05/2016 - 12/2010
2	Fatty Acids (Saturated Fatty Acids)IBA 10/2011 - 12/2009
2	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 12/2010 - 09/2006
2	AdiponectinIBA 12/2010 - 09/2006
2	LigandsIBA 09/2006 - 06/2002
2	CollagenIBA 05/2005 - 06/2002
1	Aromatase InhibitorsIBA 10/2022
1	Tamoxifen FDA LinkGeneric 10/2022
1	Enoxaparin (Lovenox)FDA LinkGeneric 05/2022
1	Dacarbazine (DIC)FDA LinkGeneric 05/2022
1	Adrenal Cortex Hormones (Corticosteroids)IBA 05/2022
1	Hemostatics (Antihemorrhagics)IBA 01/2021
1	Factor VIII (Coagulation Factor VIII)IBA 12/2020
1	emicizumabIBA 12/2020
1	Nonsense Codon (Nonsense Mutation)IBA 12/2020
1	Combined Oral ContraceptivesIBA 12/2020
1	16S Ribosomal RNAIBA 08/2020
1	Cholecalciferol (Vitamin D3)FDA Link 11/2019
1	Calcifediol (Calcidiol)FDA Link 11/2019
1	Antiphospholipid AntibodiesIBA 12/2018
1	Vitamin K FDA Link 12/2018
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 12/2018
1	fibrinogen NieuwegeinIBA 01/2018
1	Insulin (Novolin)FDA Link 04/2017

Therapy/Procedure

9	Mediterranean Diet 02/2018 - 09/2008
4	Therapeutics 12/2020 - 11/2002
4	Vegetarian Diet (Vegetarianism) 01/2018 - 05/2016
2	Ligation 01/2020 - 06/2002
1	Contraception (Birth Control) 12/2020
1	Liver Transplantation 01/2020
1	Induced Hypothermia 01/2020
1	Vegan Diet (Diet, Vegan) 11/2017
1	Radiofrequency Ablation 03/2017